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YH-53 is a potent 3CLpro inhibitor with Ki values of 6.3 nM, 34.7 nM for SARS-CoV-1 3CLpro and SARS-CoV-2 3CLpro, respectively. YH-53 strongly blocks the SARS-CoV-2 replication. YH-53 is a peptidomimetic compound with a unique benzothiazolyl ketone. YH-53
Chinese name:S-217622
English alias:N-[(1S)-1-[[[(1S)-2-(2-Benzothiazolyl)-2-oxo-1-[[(3S)-2-oxo-3-pyrrolidinyl]methyl]ethyl]amino]carbonyl]-3-methylbutyl]-4-methoxy-1H-indole-2-carboxamide
CAS No:1471484-62-4
Molecular Formula:C30H33N5O5S
Molecular Weight:575.68
SMILES:C(C)(C)C[C@H](NC(=O)C1=CC2C(=CC=CC=2OC)N1)C(=O)N[C@H](C(C1SC2=CC=CC=C2N=1)=O)C[C@@]1(CCNC1=O)[H]